Mapping the complexity and diversity of tertiary lymphoid structures in primary and peritoneal metastatic gastric cancer

by Grootjans Lab | Apr 25, 2025 | Publications

Groen-van Schooten TS, Franco Fernandez R, van Grieken NCT, Bos EN, Seidel J, Saris J, Martínez-Ciarpaglini C, Fleitas TC, Thommen DS, de Gruijl TD, Grootjans J, Derks S.J Immunother Cancer. 2024 Jul 1;12(7):e009243. doi: 10.1136/jitc-2024-009243. Read...

T-cell responses in colorectal peritoneal metastases are recapitulated in a humanized immune system mouse model

by Grootjans Lab | Apr 25, 2025 | Publications

Saris J, Bootsma S, Verhoeff J, Tuynman JB, Wildenberg ME, Rijnstra ES, Lenos KJ, Garcia Vallejo JJ, Vermeulen L, Grootjans J. Front Immunol. 2024 Jul 9;15:1415457. doi: 10.3389/fimmu.2024.1415457. eCollection 2024. Read more

Peritoneal resident macrophages constitute an immunosuppressive environment in peritoneal metastasized colorectal cancer

by Grootjans Lab | Apr 25, 2025 | Publications

Saris J, Li Yim AYF, Bootsma S, Lenos KJ, Franco Fernandez R, Khan HN, Verhoeff J, Poel D, Mrzlikar NM, Xiong L, Schijven MP, van Grieken NCT, Kranenburg O, Wildenberg ME, Logiantara A, Jongerius C, Garcia Vallejo JJ, Gisbertz SS, Derks S, Tuynman JB, D’Haens...

The unfolded protein response in immunity and inflammation

by Grootjans Lab | Feb 2, 2023 | Publications

Nat Rev Immunol. 2016 Aug;16(8):469-84. doi: 10.1038/nri.2016.62. Epub 2016 Jun 27. Grootjans J, Kaser A, Kaufman RJ, Blumberg RS. The unfolded protein response (UPR) is a highly conserved pathway that allows the cell to manage endoplasmic reticulum (ER) stress that...

Epithelial endoplasmic reticulum stress orchestrates a protective IgA response

by Grootjans Lab | Feb 2, 2023 | Publications

Science. 2019 Mar 1;363(6430):993-998. doi: 10.1126/science.aat7186. Grootjans J, Krupka N, Hosomi S, Matute JD, Hanley T, Saveljeva S, Gensollen T, Heijmans J, Li H, Limenitakis JP, Ganal-Vonarburg SC, Suo S, Luoma AM, Shimodaira Y, Duan J, Shih DQ, Conner ME,...

The Role of the Immune System in IBD-Associated Colorectal Cancer: From Pro to Anti-Tumorigenic Mechanisms

by Grootjans Lab | Nov 25, 2021 | Publications

Int J Mol Sci. 2021 Nov 25;22(23):12739. doi: 10.3390/ijms222312739. Frigerio S, Lartey DA, D’Haens GR, Grootjans J Patients with inflammatory bowel disease (IBD) have an increased incidence of colorectal cancer (CRC). IBD-associated cancer follows a...