Blog
Mapping the complexity and diversity of tertiary lymphoid structures in primary and peritoneal metastatic gastric cancer
Groen-van Schooten TS, Franco Fernandez R, van Grieken NCT, Bos EN, Seidel J, Saris J, Martínez-Ciarpaglini C, Fleitas TC, Thommen DS, de Gruijl TD, Grootjans J, Derks S.J Immunother Cancer. 2024 Jul 1;12(7):e009243. doi: 10.1136/jitc-2024-009243. Read more
T-cell responses in colorectal peritoneal metastases are recapitulated in a humanized immune system mouse model
Saris J, Bootsma S, Verhoeff J, Tuynman JB, Wildenberg ME, Rijnstra ES, Lenos KJ, Garcia Vallejo JJ, Vermeulen L, Grootjans J. Front Immunol. 2024 Jul 9;15:1415457. doi: 10.3389/fimmu.2024.1415457. eCollection 2024. Read more
Peritoneal resident macrophages constitute an immunosuppressive environment in peritoneal metastasized colorectal cancer
Saris J, Li Yim AYF, Bootsma S, Lenos KJ, Franco Fernandez R, Khan HN, Verhoeff J, Poel D, Mrzlikar NM, Xiong L, Schijven MP, van Grieken NCT, Kranenburg O, Wildenberg ME, Logiantara A, Jongerius C, Garcia Vallejo JJ, Gisbertz SS, Derks S, Tuynman JB, D'Haens GRAM,...
New publication in Nature Communications
In our latest publication in Nature Communications, we show that peritoneal resident macrophages define a metastatic site-specific immunosuppressive niche, and that targeting these peritoneal resident macrophages is a promising treatment strategy for peritoneal...
A new paper in the Journal for ImmunoTherapy of Cancer
A collaborative project with the group of Dr. Sarah Derks resulted in this publication in the Journal for ImmunoTherapy of Cancer. This paper shows that gastric cancer (GC)-derived peritoneal metastases often contain immature tertiary lymphoid structures (TLS), which...
A new paper in Frontiers Immunology
A new paper from our group has been published in Frontiers in Immunology. The paper demonstrates that T cell responses in peritoneal metastasized colorectal cancer (PM-CRC) in a humanized immune system mouse model mirror those in human PM-CRC. This makes the model...
Joep Grootjans joins Oncode Institute
Joep Grootjans joins Oncode Institute per January 1st, 2024, together with 9 other Junior Investigators and their research groups. The Junior Investigators were selected out of 72 applicants based on the quality of their science, expertise and potential to contribute...
Amsterdam Institute for Infection and Immunity (AII) Researchers Secure Four VIDI Grants
Four esteemed researchers within the Amsterdam Institute for Infection and Immunity (AII) have been granted VIDI awards by the prestigious Dutch Research Council (NWO). Dr. Sarah Derks is spearheading research in Cancer Immunology. She focuses on tackling...
IXA TKI-PPP: Joep Grootjans – IMPaCT
https://www.youtube.com/watch?v=mzuXwchZnhM TKI-PPP grant Amsterdam UMC stimulates its researchers to perform research projects together with companies in Public-Private Partnerships (PPP). The funding is provided by the Dutch government (Ministry of Economic...
The unfolded protein response in immunity and inflammation
Nat Rev Immunol. 2016 Aug;16(8):469-84. doi: 10.1038/nri.2016.62. Epub 2016 Jun 27. Grootjans J, Kaser A, Kaufman RJ, Blumberg RS. The unfolded protein response (UPR) is a highly conserved pathway that allows the cell to manage endoplasmic reticulum (ER) stress that...
Epithelial endoplasmic reticulum stress orchestrates a protective IgA response
Science. 2019 Mar 1;363(6430):993-998. doi: 10.1126/science.aat7186. Grootjans J, Krupka N, Hosomi S, Matute JD, Hanley T, Saveljeva S, Gensollen T, Heijmans J, Li H, Limenitakis JP, Ganal-Vonarburg SC, Suo S, Luoma AM, Shimodaira Y, Duan J, Shih DQ, Conner ME,...
ECCO grant for PhD student Sofia Frigerio
Sofia Frigerio received the ECCO grant of 80k from the European Crohn’s and Colitis Organisation. With funding from the ECCO, she will study the role of the immune system in the development of dysplasia and cancer in humans using novel spatial profiling techniques.