A collaborative project with the group of Dr. Sarah Derks resulted in this publication in the Journal for ImmunoTherapy of Cancer. This paper shows that gastric cancer (GC)-derived peritoneal metastases often contain immature tertiary lymphoid structures (TLS), which are associated with immune-suppressive regulatory tumor-infiltrating leukocytes. This finding aligns with the lack of response to immune checkpoint blockade and the poor prognostic features of peritoneal metastatic GC, which must be considered when optimizing immunomodulatory strategies for metastatic GC. Read the full article here: Mapping the complexity and diversity of tertiary lymphoid structures in primary and peritoneal metastatic gastric cancer
